Sodium Fusidate ointment 是什么药？

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Fucidine - General Information:
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Fucidin is effective against several bacterial species and used in the treatment of infections such as impetigo (characterised by blistering and yellowish-brown crusting of the skin), whitlow (paronchya) and inflammation of hair follicles (sycosis). It is also used to treat eczema or dermatitis that has become infected.

Fucidine Indication: For the treatment of bacterial infections.

Mechanism Of Action: Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome.

Drug Interactions: Amprenavir The protease inhibitor increases the effect and toxicity of fusidic acid
Fosamprenavir The protease inhibitor increases the effect and toxicity of fusidic acid
Nelfinavir The protease inhibitor increases the effect and toxicity of fusidic acid
Ritonavir The protease inhibitor increases the effect and toxicity of fusidic acid
Saquinavir The protease inhibitor increases the effect and toxicity of fusidic acid
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Simvastatin Increased risk of myopathy/rhabdomyolysis
Indinavir Indinavir increases the effect and toxicity of fusidic acid

Food Interactions: Take with food to reduce irritation.

Generic Name: Fusidic Acid

Synonyms: Diethanolamine fusidate; Fucidic acid; Fusidate; Fusidate Sodium; Fucidate Sodium; Fucidate

Drug Category: Antibacterial Agents

Drug Type: Small Molecule; Approved

Other Brand Names containing Fusidic Acid: Fucidin Cream 2%; Fucithalmic; Fusidine; Ramycin; Fucidin; Fucidin acid; Fucidine;

Absorption: Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Toxicity (Overdose): Not Available

Protein Binding: 97 to 99%

Biotransformation: Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

Half Life: Approximately 5 to 6 hours in adults.

Dosage Forms of Fucidine: Not Available

Chemical IUPAC Name: (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

Chemical Formula: C31H48O6

Organisms Affected: Enteric bacteria and other eubacteria